InterProScan not returning results

Sarah Atwood

• March 20, 2023 19:35

Hello,

I am not able to get any results returned from the InterProScan plugin.  Each protein I attempt results in the "Find Protein Domains With Interproscan found no results".

I am able to take the same sequence and run through the InterProScan website and it returns domains.  I have included an example protein sequence.  I have checked the plugin usage notes and ensured none of the proteins have any stop codons.

Can you help me understand why the plugin does not find any domains for this protein?

Thank you

Sarah

MDFSLFLTIVAAAIGFFVIRRFRFNPENNEIDTSSLSPSSPPSSLSSRSLSTSSTPSALSPSSASPSSSSHVWMYDVFPSFRGEDVRYNFLSHIKKEFKRKTITFFNDNGIERGESIAPELIQGIRGSKIAIVLLSTNYASSKWCLEELVEIMKCREELGQTVIAIFYKVDPSDVKKLTGDFGEVFRKTCKGKAKEEIRRWEQALEKVAVIAGYHLSNWDDEATVIENISTCVLNKLVNSPQPSHFDNLVGMSTHMENLELLLSLGSKEVRMVGIWGPSGIGKSTIARVLFNQHSHQFQFSVFMENIKRLWPRPYYDEYSVKLQLQEEFLSRVINQKDIKIQQLGVVEDRLKDKRVLAILDDVDHLLQIEAIAKEARWFGPGSWIIITTQDKRLLYAHGINQIYEVELPPDEEALEIFCMNAFCQKSPPDGFKELAWEVTRLAGKLPLGLRVMGSHFKGRPKHEWEEGLPRLRTRLNGEIENTLKFSYDALCDDNQAIFLHLACFFINEPIENVERCLEKKIVGVKGCLRVLAEKSFISFEWGRIKMHDLLALLGREIVRKQSIHEPGQRQFLVDAGDICQVLRNDTLGSRNVIGIDLDLTKLETEVKISDRVFERMPNVQFLRVKYRSIQRKPYPHSIDPVTCLPPNLIILHWDYFPMTCLPSNFNPEFLTRIILTENNYLEKLWEGNKTIRNLKLMNLSNSKNLKELPDLSTATNLQTLELSGCSSLTELPFSIGNAINLRRLNLSHCSSLMELPSSMENATDLEELNLTGCLHLAKLPSSIGNLKKLYLKDCSSLVEFPSSMENVTTLEELLLTGCSHLANLPPSIGNLKTLYLENCSSLVELPSSVRNSINLKNFSFNGCSNLVELPFYLGNATDLQRLYLRGCSSLQELPSSIGNITRLEELILEECSSLVELPSSIGNITSLEYLNLDACSSLVKLPSSIGDIINLKNLYLNGCSSLVELPSSIGNINYLKKLSLNGCSSLVELPSSIGNMTSLEELNLNGCSSLVELPSSIGNMNNLWMLYLERCSNLTALPININMKSLRVLALTDCSSLKSFPEISTNIRVLKLTGTAIEEIPPSIMSWPWLSELNMSYLENLKKSQHALYRITDLLLSDTGIQETAPWVKKERSRIRELVIKRCTEQVSFPQDCKFCKRHHFSLYKHKSNVFIVINCLKLNQETRDLIIKTSTRDFTILPGETVPTYFSYRAAGSSLSMTWNGLDTEYFPTSLRFRACLLLVYKGHVGGHRQWSEITYCIKDKLTGVERYSHRFVNLPPTPDDHLFVFEIEETVSAPELVFEFGFTNKNWEIKKCGLHPLETPSC

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• Official comment

  

  Jonas Kuhn

  • March 21, 2023 03:21

  Hi Sarah,

  which version of the InterProScan plugin do you have installed?

  You should use version 2.0, which fixes a connection issue.

  If you already have that version installed, then I would advise you to use Help --> Contact Support and 'include logs from recently run operations' so we can investigate this a bit more.

  Regards, Jonas
• 

  Sarah Atwood

  • March 22, 2023 16:26

  Hi Jonas,

  After inquiring with my internal IT support, the problem is on our end.  Thanks for the reply.  I will work with my organization to resolve the issue.

  Sarah

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• 

  Rob Citorik

  • April 01, 2023 19:22

  Sarah- any luck resolving this issue? I am having the same problem where I don't get an error but the tool returns "Find Protein Domains With Interproscan found no results", even though I have confirmed it should find multiple domains via the website.

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• 

  Sarah Atwood

  • April 04, 2023 13:28

  Hi Rob - in short, no, but my problem is the plug-in is blocked by my organization.  I wish you luck in finding the answer!

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  Rob Citorik

  • May 10, 2023 16:52

  @Sarah- random follow-up! Maybe some bug was fixed, but... I tried InterProScan and this time unchecked all of the "Applications To Run" and it worked just fine...?

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• 

  Gonzalo Mendoza

  • September 20, 2023 13:21

  @Rob, you're right. For me, unchecking TIGRFAM solved it.

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