If not, then will adding some HTTP libraries as external jars do the trick or your plugin may block the socket requests?
Does the Geneious allow me to interact with an Custom REST API?
I have my own REST server which I use for validating some Genes with our database. Is there a way to program HTTP requests within API to interact those validation requests from within the custom plugin running inside Geneious?
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A Geneious plugin is written in Java so you should be able to implement that. Yes, you can add your own jar libraries as part of your plugin. Geneious won't block socket requests from the plugin.