If possible, we recommend storing your local database on an internal hard drive or using Geneious Cloud. With any storage location, frequent backups are still recommended.
External Drive (eg. USB): Storing your data on a USB drive may make Geneious slower but is generally safe as long as you shutdown Geneious and safely eject the drive before disconnecting the drive. Be aware that disconnects are still common with external devices and these can lead to corrupt data. Therefore, it's critically important to keep frequent backups of your database using this method of storage. To use an external drive for your data, open Tools → Preferences in Geneious and change the Data Storage Location to a new folder on your drive.
Synced Storage (Dropbox, Google Drive etc): We strongly advise against storing Geneious data directly in a cloud syncing services because data can easily become corrupted. Synced storage is fine for storing backups if you have the capability to upload.